The Antonine Plague of the second century was devastating. Historians estimate that nearly 10% of the population of the Roman Empire lost their lives. While most people fled affected areas, Christians stayed behind to serve the sick and dying. Their sacrificial care, offered to both believers and nonbelievers alike, made a deep impression on the surrounding communities.
We find a similar story in Acts 11, when the young church in Antioch hears of a severe famine in Judea and responds by sending help.